Insulin Lispro (Humalog)

Page Contents

1 WHAT IS IT?
2 WHAT IS THE TIMING OF THE MEDICATION
3 WHEN DO WE USE IT?
4 WHEN DO WE AVOID USING IT?
5 HOW IS IT ADMINISTERED?
6 WHAT ARE THE SIDE EFFECTS/TOXICITY?
7 ANYTHING ELSE TO KEEP IN MIND?
8 FURTHER READING

WHAT IS IT?

Insulin Lispro (Humalog) is a rapid-acting biosynthetic human insulin analog. It works to lower blood sugar through the insulin signaling pathway (which works through various mechanistic pathways).

General mechanism of action of insulin (source)

WHAT IS THE TIMING OF THE MEDICATION

Onset: 5-15 minutes

Peak: 30-120 minutes

Duration: 3-5 hours

WHEN DO WE USE IT?

Type 1 diabetes, type 2 diabetes,

WHEN DO WE AVOID USING IT?

In patients who have hypoglycemia

HOW IS IT ADMINISTERED?

Subcutaneous injection.

WHAT ARE THE SIDE EFFECTS/TOXICITY?

Hypoglycemia

ANYTHING ELSE TO KEEP IN MIND?

Usually, the total daily insulin requirements in patients with type 1 diabetes mellitus is 0.5–1 unit/kg (source)