Trihexyphenidyl

WHAT IS IT?

Trihexyphenidyl (Artane) is a an anticholinergic medication (most specifically an anti-muscarinic).

WHEN DO WE USE IT?

Parkinson Disease: this medicaiotn can help improve tremor and rigidity, however does not address the bradykinesia experienced by these patients.

Drug induced EPS: this medication can help manage this possible side effect of antipsychotic agents/dopamine blockade.

WHEN DO WE AVOID USING IT?

In older individuals: medications with anticholinergic activity are typically avoided in older patients due to side effects.

Closed-angle glaucoma: patients with condition should avoid anticholinergic medications due to their effect of dilating the eyes.

HOW IS IT ADMINISTERED?

Administer orally

Source
Source
WHAT ARE THE SIDE EFFECTS/TOXICITY?

Anticholinergic toxicity that can manifest as:

  • Facial flushing
  • Dry mouth
  • Mydriasis/vision changes
  • Delirium/confusion
  • Urinary retention/constipation

Closed-angle glaucoma can be precipitated by this medication (because it will cause mydriasis)

FURTHER READING

DynaMed

UpToDate

 

Page Updated: 08.06.2016