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WHAT IS IT?
Desipramine (Norpramin) is a TCA antidepressant. It blocks the re-uptake of serotonin and norepinephrine.
WHEN DO WE USE IT?
Major depressive disorder: this medication is no longer a first-line therapy, however
Bulimia nervosa: antidepressants like Desipramine are effective in this condition.
Attention deficit hyperactivity disorder (ADHD): this medication is not recommended for use in children…
WHEN DO WE AVOID USING IT?
In combination with a MAOI due to the risk of serotonin syndrome.
HOW IS IT ADMINISTERED?
Oral administration
WHAT ARE THE SIDE EFFECTS/TOXICITY?
Anticholinergic effects: dry mouth, constipation, vision disturbances)
Cardiac effects such as conduction defects.
ANYTHING ELSE TO KEEP IN MIND?
Desipramine is the least sedating out of the TCA medications.
FURTHER READING
Page Updated: 08.12.2016